Enhancement of Crystallization Process of the Organic Pharmaceutical Molecules through High Pressure

The enhancement of the crystallization process through high pressures was studied by using ribavirin (RVB) as a model compound. effects pressure on thermodynamics, nucleation kinetics, and yield were evaluated discussed. solubility in three pure solvents measured at different from 283.15 to 323.15 K. results indicate that data decreased slightly when increased. induction time cooling under measured. show could significantly reduce period. Furthermore, kinetic parameters calculated according classical theory. effect anti-solvent also studied.